- Population: Did the study include people with the same diagnosis and clinical circumstances?
- Product: Were the cell source, processing and administration comparable to the proposal?
- Comparator: Was there a suitable control group and a design capable of assessing the question?
- Outcomes: Were changes meaningful for patients and measured beyond a short follow-up?
- Harms: Were adverse events reported, and was the study large enough to detect relevant risks?
- Uncertainty: What limitations, conflicts of interest and unanswered questions remain?
Publication or trial registration is not the same as approval or proof of benefit. An early clinical study can be important science while still leaving major questions unresolved.